Is there a connection between teen Gut Microbiome and IBDs and Obesity?

Background:
The number of people who have irritable bowel diseases (IBDs) and the number of obese people has been increasing since the 1940s (Jin, J. et al, 2021). It has been reported that the number of people diagnosed with IBDs has consistently increased at a varied rate of 1.2% to 23.3% per year from the 1930s until 2010 (Molodecky, N. A. et al. 2012). There are many factors that could lead to this increase in IBDs and obesity diagnoses, alterations to diet, changes to culture, and a further understanding of IBDs and obesity. Irritable Bowel Diseases (IBDs) are incurable and can involve the inflammation of any part of the digestive tract (Halfvarson, J. et al. 2017). Examples are Crohn’s disease and Ulcerative Colitis (UC) (UCLA Health). Crohn’s disease involves inflammation in the digestive tract and ulcerative colitis involves inflammation in the rectum and colon (UCLA Health). Obesity can also alter levels of inflammation, and in past studies, obesity and the level of helpful versus unhelpful gut microbes have been found to match in a predictable way (Jin, J. et al, 2021. Franzosa, E.A. et al. 2019).

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Allies or Adversaries in Health: The Role of Viruses in the Human Microbiome

Background

Coronary Heart Disease

Coronary heart disease is a major contributor to cardiovascular disease, one of the leading causes of death worldwide (Li et al., 2024). Risk factors for Coronary heart disease include a high-fat diet, smoking, alcohol abuse, and lack of physical activity. Atherosclerosis, involving the buildup of fatty deposits in arteries, is the primary cause of Coronary heart disease (Picture 1). Emerging research suggests that the gut microbiome, consisting of bacteria, viruses, and fungi, may influence cardiovascular health by affecting inflammation and lipid metabolism, both of which contribute to atherosclerosis. However, the precise mechanisms behind this relationship are still being investigated.

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Could drinking this yogurt beverage daily decrease Polycystic Ovary Syndrome symptoms?

Background

5 to 6 million American women live with Polycystic Ovary Syndrome (PCOS). According to the endocrine society, PCOS affects 7–10% of women of childbearing age and is the most common cause of infertility (Solorzano et al., 2022).  PCOS is characterized by consistent inflammation, an irregular menstrual cycle, an excess production of male hormones, cysts formed on the ovaries (which cause pain in the uterine area), and dysbiosis. Dysbiosis is defined by an imbalance in bacterial makeup, changes in bacterial metabolic activities, or changes in distribution of bacteria within the gut. It is involved in the process by which many diseases develop or progress (“pathogenesis”). There are three types of dysbiosis according to a study in an Irritable Bowel Syndrome (IBS) journal: 1) Loss of beneficial bacteria, 2) Overgrowth of potentially pathogenic bacteria, and 3) Loss of overall number of species of bacteria (DeGruttola et al., 2016).  

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