Allies or Adversaries in Health: The Role of Viruses in the Human Microbiome

Background

Coronary Heart Disease

Coronary heart disease is a major contributor to cardiovascular disease, one of the leading causes of death worldwide (Li et al., 2024). Risk factors for Coronary heart disease include a high-fat diet, smoking, alcohol abuse, and lack of physical activity. Atherosclerosis, involving the buildup of fatty deposits in arteries, is the primary cause of Coronary heart disease (Picture 1). Emerging research suggests that the gut microbiome, consisting of bacteria, viruses, and fungi, may influence cardiovascular health by affecting inflammation and lipid metabolism, both of which contribute to atherosclerosis. However, the precise mechanisms behind this relationship are still being investigated.

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The Scoop on Poop: Possible Links Between Gut Microbes and Autism Spectrum Disorder

Background:

Autism spectrum disorder (ASD) is a developmental disorder that affects communication and behavior (NIMH,  2019).   The CDC reports that about 1 in every 59 kids is identified with ASD (CDC,  2019).   It is very common for children with ASD to have some degree of gastrointestinal (GI) issues, such as constipation, diarrhea, and abdominal pain (Hsiao, 2014).   It is estimated that between 30-50% of children with ASD also have GI problems (Buie et al., 2010, McElhanon et al., 2014), but it is unknown why this is and what is causing it.   Scientists have looked into an imbalance of the gut microbiome (all the living organisms, such as bacteria, within the gut) as a potential factor in causing ASD symptoms and have found differences between the gut microbes of ASD children and neurotypical, or ‘normal’, children (children with no mental disabilities) (Finegold et al., 2002, Adams et al., 2011).   The researchers think that reductions in beneficial microbes and increases in harmful microbes could be causing ASD symptoms and associated problems.   However, we lack evidence to determine if the differences in microbes are actually the cause of the ASD symptoms, or if the ASD is causing the differences in microbes. Continue reading “The Scoop on Poop: Possible Links Between Gut Microbes and Autism Spectrum Disorder”