Inheritance of personality: How much do genes matter?

Picture of meerkats
Extremely social animals like meerkats may benefit from specializing in particular social roles to avoid social conflict, which could create distinct personalities that may persist through time (Carter et al. 2014) Photo credit: © anekoho / Fotolia

Personality. All individuals have one. Yet, what actually contributes to individuality? Although seemingly simple, personality frustrates evolutionary biologists due to its complex and convoluted nature. It is well established that personality can have important evolutionary implications (1, 2, 3, 4, 5), but determining a method to test the genetic underpinnings of personality has proven difficult. To avoid confusion, it’s important to establish exactly what “personality” means. In an evolutionary context, animal personality is the expression of repeatable differences in behavior from other members of the population (6, 7). These differences can arise from many influences, both genetic and environmental. Variation in personality also includes both permanent differences in personalities (such as an aggressive or submissive nature) and temporary environmental effects that alter the expression of personality (such as aggression when provoked) (8,9). Drs. Ned Dochtermann and Andrew Sih (among many others) are working to determine how much of an individual’s personality is inherited through time, and the evolutionary implications for the heredity of personality (10).

It is extremely useful and helps to create repeatability when you can frame aspects of personality in a mathematical context. Here, this means observing the individual variations in behavior that can be compared to the components known to impact the phenotype. The phenotype is the outward appearance of the organism; in this case it is the observable behaviors making up the personality. This approach allows for the use of statistical tools to address questions about personality variation and, importantly, it increases the scope of questions that can be asked about personality and individuality. Fundamentally, this comes down to understanding what influences phenotypic expression, the process that generates variation within a population. Phenotypic variation comes from two main sources, genetic effects and environmental effects. Genetic effects can arise through differences in alleles (additive genetic differences) or interactions between alleles (dominance and epistatic effects). Environmental effects are either permanent (e.g. parental or epigenetic effects) or temporary (9). Total phenotypic variation is the sum of each of these four components.

Personality is a subset of phenotypic variation, summing only the additive genetic variance, dominance effects, and permanent environmental effects. Therefore, personality mathematically highlights the factors that impact the expression of a trait throughout the life of the organism. For instance, ‘submissiveness’ could be quantified by the amount of genetics shared with its parents, the interaction of the alleles influencing submissiveness, and any parental or permanent environmental effects that affect the expression of submissiveness. However even though the theory is well established, the actual data collection is very difficult and work intensive.

However, thanks to these quantifying metrics, it is possible to investigate the evolutionary implications of personality through heritability. The heritability of a trait determines the degree of response exhibited by a population in response to a selection force. These forces can vary in strength and direction, and are the results of a variety of influences. If there is a strong selective pressure (for example, if it was very advantageous to have a submissive personality) but the offspring of submissive parents do not inherit that trait (their offspring’s submissiveness is not related to the parents), then the next generation offspring did not inherit that advantage. Mathematically, this is defined as the response to selection, which is equal to the heritability of the trait multiplied by the selection differential (pressure of selection). There are many ways to measure heritability, but in this case it is quantified by how much offspring resemble their parents. What Dochtermann et al. (10) aim to calculate is the heritability of personality, the relative contribution of genetic variation to the variation observed in personality. This can be measured by comparing the additive genetic differences within an individual to the amount of total phenotypic variation expressed by that individual for a particular trait (10).

Central questions:

Animal personality has interested evolutionary biologists since Darwin; however, general patterns of heritability, especially in the context of additive genetic variation, are still elusive. What many behavioral and evolutionary ecologists would like to better understand is the amount of animal personality that is genetically determined. The heritability of personality refers explicitly to this question. It measures the proportion of personality variation attributable to additive genetic variance, which allows the precise consideration of how additive genetic and non-genetic factors might influence the evolution of personality. Studies testing this ratio provide insight into how much our genes influence our personality.

A secondary question that arises from this line of inquiry is how much observations actually reveal about genes. Evolutionary inferences can be correctly drawn from phenotypic observations, which is known as the phenotypic gambit (11). This is a common and often unstated assumption in evolutionary ecology. However, is the phenotypic gambit is a legitimate assumption? Most studies looking at the evolution of behavior assume the phenotypic gambit is true (10), but it is important to test whether this assumption is appropriate because many of the inferences drawn by evolutionary ecologists hinge on the degree to which observed phenotypic variation corresponds to the underlying additive genetic variation.

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Personality can be tested in diverse taxa, ranging from water striders to zebra finches! (photo credit: Top – AlexanderY, Bottom –  Keith Gerstung via snowmanradio)

Evidence:

The heritability of personality is difficult to calculate because repeatability and heritability must both be estimated in the same data set. Repeatability refers to how likely the behavior is to be repeated and is very difficult to determine without the known genetic variation of each organism within a population. Depending on the design of the study or the limitations of the system, both repeatability and heritability can be very complicated to measure. Therefore, only a small proportion of studies were selected for meta-analysis by these authors (only 70 instances from 10 studies) (10).

Working with the available data, which spanned behavioral studies of taxa ranging from water striders and guppies, to house sparrows and red squirrels, Dochtermann et al. (10) found that 52% of personality variation is at the additive genetic level; meaning that more than half of the variation seen in personality has a genetic basis. Furthermore, these results add support to the idea that personality genes might substantially influence evolutionary responses (2). However, when different aspects of personality are evaluated individually, the results tell a slightly different story. According to the data, variation in aggression and anti-predator behaviors have the strongest genetic component, while foraging and mating behaviors show more variation and, consequently, less genetic correlation (see figure 1 for more details). These results are limited by sample size and significantly more research is needed to fully investigate the genetic influence on different aspects of personality.

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Figure 1. These results are composites of multiple studies and show the proportion of heritability, repeatability, and their ratio that is explained by additive genetic variation. Aggression and anti-predator behavior have higher means and generally lower variance than foraging, mating behaviors, and parental efforts. These results appear to show that some aspects of personality are more likely explained by additive genetic effects than others. The parental effort sample size was not large enough to include a range; therefore the results from one study are shown as lines (Figure from Dochtermann et al. 2014)

Genetic differences are likely to contribute to variation in animal personality, which meets one prerequisite of the phenotypic gambit: a component of behavior has a significant genetic correlation. The assumptions of the phenotypic gambit gain strength as the ratio of heritability to repeatability increases because the amount of variation expressed in the phenotype is more explained by genetic differences than environmental differences. Therefore, observations of these behaviors, especially aggression and anti-predatory behavior, can assume a genetic correlation. However, these results are not strong enough to show that the phenotypic gambit can be assumed in all instances (8, 10, 12)

My questions:

Why are some aspects of personality more heritable than others? Dochtermann et al. (10) demonstrated this, but there is not enough data to draw conclusions as to why. It would be interesting to address the relative fitness of each personality. One method to do this would involve creating a controlled environment where each personality could be expressed in different relative frequencies. I would expect that each personality would respond differently depending on the population background in which it was expressed because of the value of cooperation in social environments. If cheating is favored in some instances (for example, one cheating animal in the midst of many non-cheaters) it might be advantageous. However, if that same cheating individual is in a population of mostly cheaters, then only the few non-cheaters will be rewarded (see “further reading” for more information on this subject). Work has been done in Andrew Sih’s lab with water striders to investigate how personality influences sexual selection and social choices when expressed in different frequencies (13). They have found that the background in which the personality appears is very important, but more research is underway to understand why (13).

Viewing the results from a slightly different perspective, permanent environmental effects explain about 48% of personality variation. Permanent environmental effects include maternal effects, epigenetics, and long-term environmental effects; I am curious as to which of these effects has the largest impact on personality variation. Each of these components is currently being tested to answer similar questions (see 14, 15). One exciting result involves how positive feedback loops between an individual’s personality and its choice of environment influences the persistence of that personality over time. By looking at how personality determines your rank or role (social niche) in the group, lineages that consistently express the same personality are more likely to maintain the same social niche over time (16, 17). This has many interesting implications for the benefits of inheriting personality, the establishment of culture, and the impacts of personality on diversity.

Surprisingly, Dochtermann et al. (10) found that the heritability of behavior and personalities differ significantly (14% to 52% respectively); the complete heritability of personality is significantly greater than any individual aspect of personality. But what makes personality more heritable than behavior? I find it fascinating that Dochtermann et al. explain the difference as a result of temporary environmental effects (10). This implies that short-term impacts reduce the heritability of behavior but not personality as a whole, which makes me wonder about the flexibility of personality in response to rapid change. And, furthermore, how that flexibility impacts fitness during rapid changes and over longer temporal scales where these changes have become fixed (such as climatic shifts)?

As in most studies, this type of work tends in inspire more questions than it can answer. However, thanks to the work and dedication of these two labs, they are getting closer to answering questions about how and why personalities influence and constrain evolution.

 Further reading:

References

1.) Dall et al. 2012. An evolutionary ecology of individual differences. Ecol. Lett. 15, 1189-1198

2.) Dochtermann and Dingemanse. 2013. Behavioral syndromes as evolutionary constraints. Behav. Ecol. 24, 806-811.

3.) Sih et al. 2004. Behavioral syndromes: an integrative overview. Q. rev. Biol. 79, 241 – 277

4.) Sih et al. 2012. Ecological implications of behavioral syndromes. Ecol. Lett. 15, 278 – 289

5.) Wolf et al. 2007. Life-history trade-offs favor the evolution of animal personalities. Nature 447, 581-584.

6.) Bell. 2005 Behavioral differences between individuals and two populations of sticklebacks (Gasterosteus aculeatus).J. Evol. Biol. 18, 464-473

7.) Reale et al. 2007. Integrating animal temperament within ecology and evolution. Biol. Rev. 82, 291 – 318.

8.) Dingemanse and Dochtermann. 2013 Quantifying individual variation in behavior: mixed-effect modeling approaches. J. Anim. Ecol. 82, 39-54.

9.) Dingemanse and Dochtermann. 2014. Individual behavior: behavioral ecology meets quantitative genetics. In Quantitative genetics in the wild (eds A harmantier, D Garant, LEB Kruuk, pp 54-67. Oxford, UK: oxford university press.

10.) Dochtermann et al. 2015. The contribution of additive genetic variation to personality variation: heritability of personality. Proc. R. Soc. B 282:20142201

11.) Grafen. 1984 Natural selection, kin selection and group selection. In Behavioural ecology: an evolutionary approach (eds JR Krebs, NB Davies), 2nd edn, p. 62-84. Sunderland, MA: Sinauer Associates.

12.) Dochtermann and Roff. 2010. Applying a quantitative genetics framework to behavioral syndrome research. Phil. Trans. R. Soc B. 365, 4013-4020.

13.) Sih and Watters. 2005. The mix matters: behavioral types and group dynamics in water striders. Behavior, 142, 1417-1431.

14.) Weaver. 2007. Epigenetic Programming by Maternal Behavior and Pharmacological Intervention Nature Versus Nurture: Let’s Call The Whole Thing Off. Epigenetics 2(1), 22-28.

15.) Groothuis et al. 2008. Selection on personality in a songbird affects maternal hormone levels tuned to its effect on timing of reproduction. Biology Letters 4(5), 465-467.

16.) Berguller and Taborsky. 2010. Animal personality due to social niche specialization. Trends Ecol. Evol. 25, 504 – 511.

17.) Montiglio et al. 2013. Social niche specialization under constraints, personality, social interactions and environmental heterogeneity. Phil. Trans. R. Soc. B 368, 20120343.